问题出现的根本原因是芯片返回的16位数据未被正确的转换成相应的物理量，导致结果不正确。下面是一份C/C++示例代码，可以通过以下方式解决该问题：

//读取数据
void readBME280()
{
  Wire1.beginTransmission(BME280_address);
  Wire1.write(0xF7);
  Wire1.endTransmission(false);
  Wire1.requestFrom(BME280_address, 8);

  uint8_t rawData[8];
  for (uint8_t i = 0; i < 8; i++)
  {
    rawData[i] = Wire1.read();
  }

  int32_t Digital_Pressure = (rawData[0] << 12) | (rawData[1] << 4) | (rawData[2] >> 4);
  int32_t Digital_Temperature = (rawData[3] << 12) | (rawData[4] << 4) | (rawData[5] >> 4);
  int32_t Digital_Humidity = (rawData[6] << 8) | rawData[7];

  //转换为实际的温度，压力和湿度值
  double Temperature = (double)(int32_t)(Digital_Temperature) / 4096.0;
  double Pressure = (double)(int32_t)(Digital_Pressure) / 4096.0;
  double Humidity = (double)(int32_t)(Digital_Humidity) / 1024.0;

  //输出结果
  Serial.print("Temperature: ");
  Serial.print(Temperature);
  Serial.println(" degrees C ");

  Serial.print("Pressure: ");
  Serial.print(Pressure);
  Serial.println(" Pa ");

  Serial.print("Humidity: ");
  Serial.print(Humidity);
  Serial.println(" %");
}

在代码中，将芯片返回的16位数据通过按位或运算符组合成32位变量，然后将其转换为浮点数表示的实际物理量。这样就可以避免获取到负数的问题了。